影响芬太尼镇痛效应的相关基因多态性的研究进展.pdfVIP

国匾壶醛堂皇复蒸銎壹2Q!§至§旦筮3鱼鲞筮§翅!坐』△!鲤h珏塑堂：△!歇韭垫!』：y!!堑：盟丛 741 ·综述· 影响芬太尼镇痛效应的相关基因多态性的研究进展 毛元元王艳萍张卫 【摘要】背景芬太尼属中枢性麻醉镇痛药，临床上广泛用于急、慢性疼痛的治疗。研究发现芬太尼个体差异大，且与遗 传因素有关。 目的 了解影响芬太尼个体差异性的相关因素及其研究进展，为临床实现芬太尼治疗方案的个体化提供依 据。 内容 methytransferase，COMT)、斗阿片受体l(opioid 趋向芬太尼的个体化治疗依然任重而道远，遗传因素与环境因素相互作 (P-glycoprotein，P-go)基因多态性间的相互作用。 用、表观遗传学、小RNA调控将成为未来研究热点。 【关键词】芬太尼；基因多态性；个体化治疗；疼痛 Advancesinthe on of Mao studygeneticpolymorphismfentanylYnanyuau，WangYauping，ZhangWei．Departmentof A First nesthesiology，theAffiliated 450052，China Hospital，ZhengzhouUniversity，Zhengzhou Correspondingauthor：ZhangWei，Emall：zhaugw571012@126．com 【Abstract】 is usedinacute andchronic in BackgroundFentanylwidely postsurgical pain．Interindividualvariability to isa inthe of evidence a sound responsefentanylsignificantchallengemanagementpain．Considerableconcerning genetic ofthishuman has researchonthefieldofa of background intervariabilityprompted personalizedtherapy．Andgeneticpolymorphisms and 1)，cytochrome(CY)P450，CYP3A4／5 catecholamine-O-methytransferase(COMT)，opioidreceptor斗1(OPRM P-glycoprotein studied Tosummarize dataassociatedwith encounteredin (P-gp)arcmostly．Objective pharmacogenetic fentanylfrequendy care This relatedto reviewfocuseson of authors’ managedsettings．Content fentanyl，and findings pharmacogenetics highlights viewsonfutureclinical of Personali