Assessing+Adverse+Effects+of+Aroclor+1254+on+Perinatally+Exposed+Rat+Offspring.pdfVIP

Biomed Environ Sci, 2015; 28(9): 687-690 687 Letter to the Editor Assessing Adverse Effects of Aroclor 1254 on Perinatally Exposed Rat Offspring* # TANG Wei, CHENG Jin Ping , YANG Yi Chen, and WANG Wen Hua To assess the neurotoxic effects and redox to A1254 (a commercial mixture of PCBs), the levels responses of Aroclor 1254 (A1254) on perinatally of SOD, GSH-Px, LPO, NO, and NOS in the brain, liver, exposed rat offspring, A1254 was administered by and kidney were determined. In addition, we carried gavage from gestational day (GD) 6 to postnatal day out righting reflex, cliff drop, and negative geotaxis (PND) 21. Neurobehavioral development, tests to study the effects on neurobehavioral antioxidant enzyme activities, lipid peroxidation development. (LPO), nitric oxide (NO), and NO synthase (NOS) The dose of A1254 (1.5 mg/kg) in this study was levels were analyzed in the offspring. approximately 10 times higher than the mean level Neurobehavioral development analysis revealed of ΣPCBs in female human adipose tissue. The period delayed appearance of the righting reflex, negative of administration [gestational day (GD) 6 to geotaxis, and cliff drop test responses in A1254 postnatal day (PND) 21] was chosen because it exposed group. Developmental A1254 exposure encompasses the formatio