Chitosan-collagen+porous+scaffold+and+bone+marrow+mesenchymal+stem+cell+transplantation+for+ischemic+stroke.pdf

NEURAL REGENERATION RESEARCH September 2015,Volume 10,Issue 9 RESEARCH ARTICLE Chitosan-collagen porous scaffold and bone marrow mesenchymal stem cell transplantation for ischemic stroke 1, 2, # 3, # 1, * 1 4 4 3 3 Feng Yan , Wei Yue , Yue-lin Zhang , Guo-chao Mao , Ke Gao , Zhen-xing Zuo , Ya-jing Zhang , Hui Lu 1 Department of Neurosurgery, the Third Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi Province, China 2 Department of Neurosurgery, the Fourth People’s Hospital of Shaanxi, Xi’an, Shaanxi Province, China 3 Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China 4 Department of Neurosurgery, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China Abstract *Correspondence to: In this study, we successfully constructed a composite of bone marrow mesenchymal stem cells Yue-lin Zhang, M.D., and a chitosan-collagen scaffold in vitro, transplanted either the composite or bone marrow zhangyuelin68@163.com mesenchymal stem cells alone into the ischemic area in animal models, and compared their effects. At 14 days after co-transplantation of bone marrow mesenchymal stem cells and the hi- # These authors contributed equally to tosan-collagen scaffold, neurological function recovered noticeably. Vascular endothelial growth this work. factor expression and nestin-labeled neural precursor cells were detected in the ischemic area,