CTLA-4++49A-G多态性与多发性硬化相关性的meta分析.pdf

·250· CTLA一4+49A／G 多态性与多发性硬化 相关性的 meta分析 王健健 陈丽霞 张荟雪 李杰 王丽华 摘要：目的 探讨CTLA一4+49A／G多态性与多发性硬化(MS)的相关性。方法通过检索PubMed数据 用RevMan4．2统计软件对其结果进行分析。结果共纳入25个以高加索和亚洲人群为研究对象的MS病例 例。各研究的等位基因和基因型频数结果未见明显发表偏倚。25个研究合并后，G／A、GG+GA／AA、GG／GA 0．22)。结论CTLA4+49A／G多态性与MS无相关性。 关键词：细胞毒性T淋巴细胞相关抗原4；多发性硬化；多态性；Meta分析 中图分类号：R744．5+1文献标识码：A 文章编号：1006—2963(2015)04—0250—04 AssociationbetweentheCTLA-4+49 and WANGian— A／G sclerosis：a J polymorphismmultiple meta-analysis Jan，CHENLixiaZHANGHuixue，LI Second j Jie，WANG ofNeurology，The Lihua。．。Deparentment HarbinMedical 150086，China AffiliatedHospitalof University，HarbinHeilongjiang author：WANG Corresponding Lihua，Email：wanglh211@163．corn ABSTRACT： To theassociationbetweenthe associated objectiveexplore cytotoxicT—lymphocyte and sclerosis(MS)．MethodsTheliteraturewere antigen一4(CTLA一4)+49A／Gpolymorphismmultiple searched thePubMeddatabasefromtheestablishmentofdatabasetill 2013to studies byusing Septemberidentify inwhichtheCTLA-4 was inMS wasconductedonthe polymorphismanalyzed patients．Ameta—analysis associationsbetween andMS．PooledORvalueand95％C1werecalculatedfor CTLA一4+49A／Gpolymorphism each RevMan4．2 Atotal25studieswereincludedinthis studybyusing software．Resultsof meta—analysis． was Caucasian(4663and4249 controls)and