Dynamic+Changes+in+DNA+Damage+and+Repair+Biomarkers+with+Employment+Length+among+Nickel+Smelting+Workers.pdf

Biomed Environ Sci, 2015; 28(9): 679-682 679 Letter to the Editor Dynamic Changes in DNA Damage and Repair Biomarkers with Employment Length among Nickel Smelting Workers* 1,^ 1,^ 2 3 4 WU Shan , BAI Ya Na , PU Hong Quan , HE Jie , ZHENG Tong Zhang , 2 3,# 5,# LI Hai Yan , DAI Min , and CHENG Ning Our study explored the dynamic changes in and have a significantly high mortality rate from lung the relationship between the DNA damage marker cancer in a retrospective cohort study based in 8-hydroxy-2-deoxyguanosine (8-OHdG) and the Jinchang[2]. Currently, the molecular mechanisms by DNA repair marker 8-hydroxyguanine DNA which nickel compounds cause lung cancer remain glycosidase 1 (hOGG1) according to the length of unclear, but research on the intermediate causal occupational employment in nickel smelting mechanisms between nickel exposure and lung workers. One hundred forty nickel-exposed cancer have shown that DNA damage by nickel smelting workers and 140 age-matched unexposed compounds is an important carcinogenic office workers were selected from the Jinchang mechanism[3]. cohort. The 8-OHdG levels in smelting workers was Env