In+search+for+novel+strategies+towards+neuroprotection+and+neuroregeneration：is+PPARα+a+promising+therapeutic+target-.pdf

NEURAL REGENERATION RESEARCH September 2015,Volume 10,Issue 9 HIGHLIGHTS mechanisms of action. On the other hand, the largely over- In search for novel strategies lapping action of the three receptors, recently synthesized by Aleshin and co-workers in the “PPAR triad”concept (Fidaleo towards neuroprotection and et al., 2014) should prompt the researchers to equally take neuroregeneration: is PPARα a into consideration all the isotypes, when studying physio- logical or pathological models. Despite this notion, the vast promising therapeutic target? majority of investigations has so far dealt with PPARγ and its agonists, while relatively few studies have addressed the α β δ role of PPAR and / . In this perspective, we will focus on PPARα, with special ref- Peroxisome proliferator activated receptors: In the early erence to its potential as a therapeutic target against neurode- 1990s, seminal work on rodent liver demonstrated that the generation. Distribution of the receptor in normal and patho- hypolipidemic effect of xenobiotics, referred to as peroxi- logical CNS will be briefly reviewed and related with that of its some proliferators, was mediated by a member of steroid endogenous ligands, in or