原创力文档Effect of 4-hydroxynonenal on phosphatidylethanolamine containing condensed monolayer and on its interaction with apolipoprotein A-I》.pdfVIP
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Effect of 4-hydroxynonenal on phosphatidylethanolamine containing condensed monolayer and on its interaction with apolipoprotein A-I》.pdf
FEBS Letters 579 (2005) 5074–5078 FEBS 29891
Effect of 4-hydroxynonenal on phosphatidylethanolamine
containing condensed monolayer and on its interaction
with apolipoprotein A-I
a,* a b b
Marie-France Lecompte , Jean Clavilier , Corinne Rolland , Xavier Collet ,
` a, Robert Salvayrea
Anne Negre-Salvayre
a ´
INSERM U-466, Biochemistry Department, IFR31, CHU Rangueil – 1 Avenue Jean Poulhes, TSA 50032-31059, Toulouse Cedex 9, France
b INSERM U-563, CHU Purpan, Toulouse, France
Received 25 June 2005; revised 25 July 2005; accepted 26 July 2005
Available online 15 August 2005
Edited by Sandro Sonnino
Apolipoprotein A-I (apoA-I), the major apoprotein moiety
Abstract 4-Hydroxynonenal (4HNE), generated during poly-
unsaturated fatty acid oxidation, is present in atherosclerotic le- of the antiatherogenic and cardioprotective HDL, promotes
sions. As 4HNE is able to react with phosphatidylethanolamine reverse cholesterol transport from peripheral tissues to the li-
(PE), we investigated, using AC polarography, whether it
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