Functional characterization of TRAP1-like protein involved in modulating fibrotic processes mediated by TGF-βSmad signaling in hypertrophic scar fibroblasts》.pdfVIP

E X P E R I M E N T A L C E L L R E S E A R C H 3 3 2 ( 2 0 1 5 ) 2 0 2 – 2 1 1 Available online at journal homepage: /locate/yexcr Research Article Functional characterization of TRAP1-like protein involved in modulating fibrotic processes mediated by TGF-β/Smad signaling in hypertrophic scar fibroblasts a,b, 1 b, 1 a a a c a,n X. Wang , J. Chu , C.J. Wen , S.B. Fu , Y.L. Qian , Y. Wo , C. Wang , D.R. Wanga,n aDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People ’s Hospital, Affi liated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China bDepartment of Pediatric Surgery, Shanghai Children ’s Medical Center, Affi liated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China cDepartment of Anatomy, Institutes of Medical Sciences, Affi liated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China a r t i c l e i n f o r m a t i o n a b s t r a c t Article Chronology: The transforming growth factor-β1 (TGF-β)-mediated signaling pathway is believed to be closely Received 12 October 2014 associated with wound healing and scar formation, in which TRAP1-like protein (TLP) plays a role Received in revised form in regulating the balance of Smad2 vs. Smad3 signaling. Our previous study revealed the relation 23 January 2015 between TLP and collagen synthesis in normal human skin fibroblasts. Here, we present a Accepted 24 January 2015 detailed analysis of the effects of TLP on the p