High-density lipoprotein-associated apolipoprotein A-I the missing link between infection and chronic inflammation》.pdfVIP

Autoimmunity Reviews 1 (2002) 111–117 High-density lipoprotein-associated apolipoprotein A-I: the missing link between infection and chroni cinflammation? Danielle Burger*, Jean-Michel Dayer Division of Immunology and Allergy (Hans Wilsdorf Laboratory), Department of Internal Medicine, University Hospital, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland Received 8 October 2001; a epted 29 October 2001 Abstract The etiology of chroni cimmuno-inflammatory diseases including rheumatoid arthritis (RA), multiple sclerosis (MS), systemi clupus erythematosus (SLE), and atherosclerosis is far from being elucidated. It is generally a epted that multiple factors are involved in the development of such pathologies, including factors of geneti susceptibility that interact in complex ways with diverse environmental factors, i.e. gender, nutrition, environment, etc. Furthermore, infection has often been pinpointed as playing a causal role. However, no distinctive pattern has yet emerged from the tremendous number of compiled results that would provide a generally a eptable hypothesis of the etiology of immuno-inflammatory diseases, and the possibility of a persistent antigeni cstimulus arising from an infection cannot be confirmed or refuted. At the cellular level, chroni cinflammation is characterized by the infiltration of immuno-inflammatory cells into the target tissue, which mostly precedes tissue damage. At the inflammatory site, monocytes and T lymphocytes are in close proximity. We have demonstrated that contact- mediated activation of monocytes by stimulated T l