Proton versus conventional radiotherapy for pediatric salivary gland tumors Acute toxicity and dosimetric characteristics》.pdf

Radiotherapy and Oncology 116 (2015) 309–315 Contents lists available at ScienceDirect Radiotherapy and Oncology journal homepage: www.th Protons in pediatric salivary tumors Proton versus conventional radiotherapy for pediatric salivary gland tumors: Acute toxicity and dosimetric characteristics Stephen R. Grant a, David R. Grosshans b, Stephen D. Bilton b, John A. Garcia b, Mayank Amin b, Mark S. Chambers b, Susan L. McGovern b, Mary F. McAleer b, William H. Morrison b, Winston W. Huh c, Michael E. Kupferman d, Anita Mahajan b,⇑ a Baylor College of Medicine; b Department of Radiation Oncology; c Division of Pediatrics; and d Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, United States a r t i c l e i n f o a b s t r a c t Article history: Purpose: We evaluated acute toxicity profiles and dosimetric data for children with salivary gland tumors Received 5 May 2015 treated with adjuvant photon/electron-based radiation therapy (X/E RT) or proton therapy (PRT). Received in revised form 12 July 2015 Methods and materials: We identified 24 patients who had received adjuvant radiotherapy for salivary Accepted 18 July 2015 gland tumors. Data were extracted from the medical records and the treatment planning systems. Available online 28 July 2015 Toxicity was scored according to the Common Terminology Criteria for Adverse Effects 4.0. Results: Eleven patients received X/