PSCDGs of mouse multipotent adult germline stem cells can enter and progress through meiosis to form haploid male germ cells in vitro》.pdf

Differentiation 80 (2010) 184–194 Contents lists available at ScienceDirect Differentiation journal homepage: /locate/diff PSCDGs of mouse multipotent adult germline stem cells can enter and progress through meiosis to form haploid male germ cells in vitro Jessica Nolte a, Hans W. Michelmann b, Marieke Wolf c, Gerald Wulf d, Karim Nayernia e, Andreas Meinhardt f, Ulrich Zechner c, Wolfgang Engel a,n a ¨ ¨ Institute of Human Genetics, University of Gottingen, 37073 Gottingen, Germany b ¨ ¨ Department of Obstetrics and Gynecology, University of Gottingen, 37073 Gottingen, Germany c Institute of Human Genetics, University of Mainz, 55131 Mainz, Germany d ¨ ¨ Department of Hematology and Oncology, University of Gottingen, 37073 Gottingen, Germany e Institute of Human Genetics/North East England Stem Cell Institute (NESCI), Newcastle University, Newcastle upon Tyne, UK f Department of Anatomy and Cell Biology, University of Giessen, 35385 Giessen, Germany a r t i c l e i n f o a b s t r a c t Spermatogonial stem cells (SSCs) provide the basis for spermatogenesis throughout adult life by Keywords: undergoing self-renewal and differentiation into sperm. SSC-derived cell lines called multipotent adult Multipotent adult germline stem cells germline stem cells (maGSCs) were recently shown to be pluripotent and to have the same potential as Spermatogonial stem cells