Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson’s disease》.pdf

Toxicology Letters 238 (2015) 70–82 Contents lists available at ScienceDirect Toxicology Letters journal homepage: www.elsev /locate/toxlet Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson’s disease a,1 a,b,1 a a a Jiaojiao Qin , Meilong Wu , Shu Yu , Xiaorong Gao , Jingjing Zhang , a,b a,b a,b a,b a,* a,* Xingyue Dong , Jinyan Ji , Yuxi Zhang , Lin Zhou , Qi Zhang , Fei Ding aJiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong JS 226001, PR China b Medical School, Nantong University, 19 Qixiu Road, Nantong JS 226001, PR China H I G H L I G H T S PQQ conferred protection in rotenone-induced PD models both in vitro and in vivo. PQQ increased antioxidant ability and mitochondrial function in PD models. PQQ affected dopamine redistribution in rotenone-induced PD models. A R T I C L E I N F O A B S T R A C T Article history: Pyrroloquinoline quinone (PQQ), a redox cofactor in the mitochondrial respiratory chain, has proven to Received 13 May 2015 protect neurons against glutamate-induced damage both in vitro and in vivo. This study was aimed to Received in revised form 22 July 2015 investigate the possible neuroprotective effects of PQQ in ro