Radiation activated CHK1MEPE pathway may contribute to microgravity-induced bone density loss》.pdf
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Radiation activated CHK1MEPE pathway may contribute to microgravity-induced bone density loss》.pdf
Accepted Manuscript
Radiation activated CHK1/MEPE pathway may contribute to microgravity-induced bone
density loss
Xiangming Zhang, Ping Wang, Ya Wang
PII: S2214-5524(15)00078-4
DOI: /10.1016/j.lssr.2015.08.004
Reference: LSSR 72
To appear in: Life Sciences in Space Research
Received date: 1 August 2015
Revised date: 29 August 2015
Accepted date: 31 August 2015
Please cite this article in press as: Zhang, X., et al. Radiation activated CHK1/MEPE pathway may contribute to microgravity-induced bone
density loss. Life Sci. Space Res. (2015), /10.1016/j.lssr.2015.08.004
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing
this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is
published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all
legal disclaimers that apply to the journal pertain.
1 Submit Revised Research Article (LSSR-D-15-00053) Aug 30, 2015
2
3 Radiation activated CHK1/MEPE pathway may contribute to microgravity-
4 induced bone density loss
5
*
6 Xiangming Zhang, Ping Wang and Ya Wang
7
8 Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer
9 Institute of Emory University, Atlanta, GA 30322, USA
10
11
12 Running Title: CHK1 affects bone metabolism
13 Key words: Ionizing Radiation, Microgravity, CHK1, MEPE, ASARM Secretion, Bone Density
14 Loss
15
16
*
17 Corresponding author:
18 Ya Wang, MD, PhD
19
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