Radical-mediated step-growth Preparation of hybrid polymer monolithic columns with fine control of nanostructural and chromatographic characteristics》.pdf

Journal of Chromatography A, 1412 (2015) 112–125 Contents lists available at ScienceDirect Journal of Chromatography A j o u r n a l h o me p a g e : w w w. elsev /locate/chro ma Radical-mediated step-growth: Preparation of hybrid polymer monolithic columns with fine control of nanostructural and chromatographic characteristics Filipa Alves, Ivo Nischang ∗,1 Institute of Polymer Chemistry,Johannes Kepler University Linz, A-4060 Leonding, Austria a r t i c l e i n f o a b s t r a c t Article history: The currently most successful type of porous polymer monoliths utilized in chromatography is prepared Received 24 June 2015 by free-radical cross-linking (co)polymerization in porogenic solvents and a single-step molding process. Received in revised form 5 August 2015 Though such types of materials are well-recognized in the scientific community, they suffer from their Accepted 10 August 2015 multi-scale heterogeneity originating from the nanoscale through to their microscale and ultimately Available online 13 August 2015 limited performance on their macroscale. This is in particular true when estimating their performance under equilibrium (i.e. isocratic) elution conditions for retained compounds. Keywords: In this contribution, we study a new concept in the preparation of porous monolithic hybrid materials Adsorption Click chemistry based on polyhedral oligom