Rapid regulation of apolipoprotein A-I secretion in HepG2 cells by a factor associated with bovine high-density lipoproteins》.pdf
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Rapid regulation of apolipoprotein A-I secretion in HepG2 cells by a factor associated with bovine high-density lipoproteins》.pdf
B~~~irnjc# et B~o~hysicaActa, 1046 (1990) 223-228 223
Elsevier
BBALIP 53478
Rapid regulation of apolipoprotein A-I secretion in HepG2 cells
by a factor associated with bovine high-density lipoproteins
Subr~a~~ R~g~athan and Bruce A. Kottke
Atherosclerosis Research Unil, Mayo Clinic and Foundation, Rochester, MN (US.A.J
(Received 23 October 1989)
{Revised manuscript received 26 April 1990)
Key words: Apolipoprotein A-I; HDL; Secretion; HepG2 cell
The effect of fetal bovine serum (FBS) on the secretion of a~li~protein A-I (apo A-I) by HepG2 cells was studied.
The cells incubated with FBS always secreted more apo A-I than the cells incubated with serum-free medium. The
changes in the rate of apo A-I secretion were observed within 1h after addition or depletion of serum. The high-density
lipoproteins (HDL) or the lipoprotein-deficient sernm (LPDS) obtained from FBS also stimulated apo A-I secretion
rapidly to the same Ievel as obtained with FBS. Addition of low-density lipoproteins did not have any effect. The rate of
general protein synthesis was not affected by short-term in~bations with or without serum or HDL. The rate of
apolipoprotein E secretion by these cells did not change significantly, parallel to the changes in ape A-I secretion in the
presence or absence of FBS. It is concluded that serum may have a fact
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