Rare 2-phenylpyran-4-ones from the seagrass-derived fungi Polyporales PSU-ES44 and PSU-ES83》.pdfVIP

Tetrahedron 69 (2013) 6981e6986 Contents lists available at SciVerse ScienceDirect Tetrahedron journal homepage: www.el /locate/tet Rare 2-phenylpyran-4-ones from the seagrass-derived fungi Polyporales PSU-ES44 and PSU-ES83 Vatcharin Rukachaisirikul a, *, Sirikan Kannai a, Saranyoo Klaiklay a, Souwalak Phongpaichit b, Jariya Sakayaroj c a Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand b Natural Products Research Center and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand c National Center for Genetic Engineering and Biotechnology, Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand a r t i c l e i n f o a b s t r a c t Article history: Eight new 2-phenylpyranon-4-one derivatives, polyporapyranones AeH (1e8), together with eight Received 10 April 2013 known compounds were isolated from two seagrass-derived fungi Polyporales PSU-ES44 and PSU-ES83. Received in revised form 3 June 2013 Their structures were determined by spectroscopic methods. 2-Phenylpyran-4-one derivatives are rare Accepted 17 June 2013 natural products. Some isolated compounds were evaluated for cytotoxic activity against human breast Available online 25 June 2013 cancer (MCF-7) and noncancerous Vero (African green monkey kidney fibroblasts) cell lines.