Radiosensitivity index predicts for survival with adjuvant radiation in resectable pancreatic cancer》.pdf

Radiotherapy and Oncology xxx (2015) xxx–xxx Contents lists available at ScienceDirect Radiotherapy and Oncology journal homepage: www.th Original article Radiosensitivity index predicts for survival with adjuvant radiation in resectable pancreatic cancer Tobin Strom a, Sarah E. Hoffe a, William Fulp c, Jessica Frakes a, Domenico Coppola b, Gregory M. Springett b, Mokenge P. Malafa b, Cynthia L. Harris b, Steven A. Eschrich c, Javier F. Torres-Roca a,⇑, Ravi Shridhar a,⇑ a Department of Radiation Oncology; b Gastrointestinal Tumor Program; and c Department of Biomedical Informatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA a r t i c l e i n f o a b s t r a c t Article history: Background and purpose: Adjuvant radiation therapy for resectable pancreatic cancer remains controver- Received 7 March 2015 sial. Sub-populations of radiosensitive tumors might exist given the genetic heterogeneity of pancreatic Received in revised form 26 June 2015 cancers. We evaluated whether RSI is predictive of survival in pancreatic cancer treated with radiation. Accepted 16 July 2015 Materials and methods: We identified 73 genomically-profiled pancreas cancer patients treated with Available online xxxx upfront surgery between 2000 and 2011 (48 radiation, 25 no radiation). Briefly, RSI score is derived from the expression of 10 specific genes and a linear regression algorithm modeled on SF2 of 48 cancer cells. Keywords: The primary