Rationalizing thymic selection for functional T-cells A commentary》.pdf

Cellular Immunology xxx (2015) xxx–xxx Contents lists available at ScienceDirect Cellular Immunology journal homepage: www.else /locate/ycimm Review article Rationalizing thymic selection for functional T-cells: A commentary Melvin Cohn Conceptual Immunology Group, The Salk Institute, 10010 N. Torrey Pines Rd., La Jolla, CA 92037-1099, USA a r t i c l e i n f o a b s t r a c t Article history: What are the minimum specificity requirements of a thymic selective process that establishes (1) restric- Received 10 July 2015 tive recognition of peptide, (2) the Self (S)–Nonself (NS) discrimination, and (3) the categories of effector Revised 9 September 2015 function? Given an answer to that question, how well does it fit with the observed selective processes in Accepted 24 September 2015 thymus where T-cells are generated? Any discrepancies between the two must be rationalized. The goal Available online xxxx of this essay is to attempt just that. 2015 Published by Elsevier Inc. Keywords: Thymic positive selection Thymic negative selection T-helpers T-suppressors Cytotoxic T-cells Peripheralized T-cells 1. Introduction of protein. These PR-complexes are the ligands recognized by the