Rationally designed non-enzymatic fluorogenic ‘turn-on’ probe for uric acid》.pdf

Dyes and Pigments 121 (2015) 1e6 Contents lists available at ScienceDirect Dyes and Pigments journal homepage: /locate/dyepig Rationally designed non-enzymatic fluorogenic ‘turn-on’ probe for uric acid a, 1 b, 1 b, 1 b c Tuhin Pradhan , Sukhendu Maiti , Rajesh Kumar , Yun Hak Lee , Jong Wan Kim , Joung Hae Lee d, **, Jong Seung Kim b, * a Department of Chemistry, Vel Tech Dr. RR Dr. SR Technical University, Avadi, Chennai 600062, India b Department of Chemistry, Korea University, Seoul 136-701, Republic of Korea c Department of Laboratory Medicine, College of Medicine, Dankook University, Cheonan 330-715, Republic of Korea d Korea Research Institute of Standards and Science, Daejon 305-600, Republic of Korea a r t i c l e i n f o a b s t r a c t Article history: The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts Received 11 March 2015 as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the Received in revised form detection of uric acid in serum samples over a wide range of concentrations (lower: ~60 mM, higher: 30 April 2015 ~700 mM and normal: ~120e380 mM) with ‘turn-on’ fluorogenic behaviour. Accepted 3 May 2015