Recent progress of sugar amino acids Synthetic strategies and applications as glycomimetics and peptidomimetics》.pdf

Chinese Chemical Letters 26 (2015) 922–930 Contents lists available at ScienceDirect Chinese Chemical Letters jo u rn al h om epag e: ww w.els evier.c o m/lo cat e/cc let Review Recent progress of sugar amino acids: Synthetic strategies and applications as glycomimetics and peptidomimetics Guang-Zong Tian a,c,1, Xiao-Li Wang a,c,1, Jing Hu b, Xue-Bin Wang a,c, Xiao-Qiang Guo a,c, Jian Yin a,c,* a Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China b Wuxi Medical School, Jiangnan University, Wuxi 214122, China c Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, China A R T I C L E I N F O A B S T R A C T Article history: In order to meet the increasing demands for the development of large varieties of new molecules for Received 16 December 2014 discovering new drugs and materials, organic chemists are developing many novel multifunctional Received in revised form 16 January 2015 building blocks, which are assembled rationally to create ‘nature-like’ and yet unnatural organic Accepted 27 March 2015 molecules with well-defined structures and useful properties. Sugar amino acids (SAAs), the Available online 18 April 2015 carbohydrate derivatives bearing both amino and carboxylic acid functional groups, are important