Reconstitute the damaged heart via the dual reparative roles of pericardial adipose-derived flk-1+ stem cells》.pdf

International Journal of Cardiology 202 (2016) 256–264 Contents lists available at ScienceDirect International Journal of Cardiology journal homepage: www. else vi er. com/ locate/ijcard Research article Reconstitute the damaged heart via the dual reparative roles of pericardial adipose-derived flk-1+ stem cells Xiaoming Wang a,1,2, Xueqing Liu b,1,2, Hui Zhang c, Liangming Nie c, Min Chen d,⁎,2, Zhaoping Ding e,2,⁎⁎ a Department of Cardiac Surgery, Zhejiang Hospital, Lingyin Rd. 12, 310013 Hangzhou, China b Department of Cardiology, Danyang Peoples Hospital, West Xinmin Rd. 5, 212300 Danyang, China c Department of Cardiothoracic and Operation Theater, Zhejiang Provincial Peoples Hospital, Shangtang Rd. 158, 310014 Hangzhou, China d School of Medical Science and Laboratory Medicine, Jiangsu University, XueFu Rd. 301, Zhenjiang, China e Institute of Molecular Cardiology, Heinrich-Heine University of Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany a r t i c l e i n f o a b s t r a c t Article history: Background: The pericardial adipose derived stromal cells (pADSC) own a developmental origin from the “second Received 10 February 2015 heart field” and thus favor myogenic differentiation. The present experiments extended our previous observation Received in revised form 29 May 2015 by defining a subset of pADSC marked with the expression of flk-1, a type II receptor for VEGF to efficiently en- Accepted 2 September 2015 hance cardiac repair. Available online 6 September 2015