糖皮质激素口服联合鼓室内注射治疗重度和极重度突发性聋.pdfVIP

CHIN ARCH OTOLARYNGOL HEAD NECK SURG / September 2015, Vol.22, No.9 459 DOI: 10.16066/j.1672-7002.2015.09.008 糖皮质激素口服联合鼓室内注射治疗重度和极重度突发性聋 刘璐，钟时勋 重庆医科大学附属第一医院耳鼻咽喉科，重庆　400016 [摘　要]　目的　观察糖皮质激素全身应用和鼓室内注 ) 射联合治疗重度和极重度突发性聋的临床疗效，以探索糖 [ABSTRACT]　OBJECTIVE　To evaluate the efficacy 皮质激素治疗突发性聋的方法。 　对54例重度和极 of combined oral and intratympanic glucocorticoids 方法 重度突发性聋患者的临床资料进行回顾性分析，所有患者 treatment for severe to profound sudden sensorineural 均给予口服激素、改善微循环、溶栓抗凝等治疗，同意加用 hearing loss(SSNHL). METHODS　Fifty-four patients 鼓室内注射激素的患者为治疗组，其余患者为对照组，治 with severe to profound SSNHL were retrospectively 疗2周后复查纯音测听。 　治疗组和对照组患者平均 studied. They were treated with oral steroids, vasodilators, 结果 听阈改善均具有显著统计学意义，但两组之间疗效无差异 anticoagulants. The patients who accepted intratympanic P =0.194 ）。治疗组与对照组中重度突发性聋患者间疗效 （ methylprednisolone sodium succinate were included the 无差异（P =0.251 ），两组中极重度突发性聋患者间疗效也 therapy group, the others were included in the control 无差异（P =0.380 ）。 　糖皮质激素全身应用联合鼓室 结论 group. Hearing improvements were analyzed respectively 内注射治疗重度和极重度突发性聋有效，但并不能得到较 after two weeks. RESULTS　Hearing in both groups were 单独全身用药更好的疗效。 improved significantly after treatment(P ＜0.01), but there [关键词]　听觉丧失，突发性; 糖皮质激素类; 中耳 was no difference in hearing improvements between two groups(P =0.194). The efficacy for severe SSNHL patients in Combined oral and intratympanic glucocorticoids therapy group was equal to those who were in control group treatment for severe to profound sudden sensorineural (P =0.251), so was the efficacy for profound SSNHL patients hearing loss