食欲素功能研究及在肿瘤治疗方面应用的前景.pdfVIP

·64· 肿瘤代谢与营养电子杂志  2015年9月第2卷第3期              Electron J Metab Nutr Cancer，Sep. 2015，Vol. 2， No. 3 ·综述· 食欲素功能研究及在肿瘤治疗方面应用的前景 1 1 1 2 1 2 刘兵兵， 杜红珍， 李增宁， 石汉平（ 河北医科大学第一医院临床营养科，石家庄 050031； 中山大学附 属第一医院外科，广州 510080） 摘要：目的 阐述食欲素的生理功能以及与瘦素和恶性肿瘤的相关性，对其在肿瘤治疗等方面的应用前景进行展望。方 法 回顾和研究近几年来国内外发表的有关食欲素的生理作用，与瘦素和恶性肿瘤相关性的中英文相关文献。结果 食欲素 不仅可参与调节能量代谢和摄食行为，还在睡眠-觉醒周期、应激、药物成瘾复吸、胰岛素分泌、胃酸分泌等方面有着非 常重要的作用，且已有文献证实食欲素可影响恶性肿瘤患者的食欲和促进恶性肿瘤细胞的凋亡。结论 食欲素在开发治疗糖 尿病、药物成瘾和嗜睡症的新型药物及改善恶性肿瘤患者食欲和促进恶性肿瘤细胞凋亡方面具有应用前景。 关键词：食欲素；食欲素受体；瘦素；恶性肿瘤 Function of orexin and its application in the treatment of tumor 1LIU Bing-bing, 1DU Hong-zhen, 1LI Zeng-ning, 2SHI Han-ping 1Department of Clinical Nutrition, the First Hospital of HeBei Medical University, Shijiazhuang 050031, China; 2Department of Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China Abstract: Objective To elaborate the physiological functions of orexin and the correlation between leptin and malignant tumor, in addition to look forward its application prospect in tumor. Methods We reviewed and researched the domestic and foreign published literature about the physiological function of orexin, and the relationship between leptin and malignant tumor. Results Orexin can not only be involved in the regulation of energy metabolism, feeding behavior, but also play a very important role in the sleep wake cycle, stress, drug addiction and relapse, insulin secretion, gastric acid secretion, and many studies have confirmed that orexin can affect the appetite of patients with malignant tumor and promote the apoptosis of cancer cells. Conclusions Orexin has the application prospect in drug discovery for treating diabetes, drug addiction and narcolepsy, improving the poor quality of appetite in patients with malignant tumor and promoting the apoptosis of malignant tumor cells. Key words: Orexin; Orexin receptor; Leptin;