毕业设计（论文）-脂质体包埋技术在抗癌药物中应用的研究进展.docVIP

脂质体包埋技术在抗癌药物中应用的研究进展 专 业： 药 学 学生姓名： XXX 学 号： 指导教师： XXX 2013年5月20日 脂质体包埋技术在抗癌药物中应用的研究进展 摘:为了综述研究脂质体包埋技术在抗癌药物应用中的研究进展，根据脂质体包埋技术抗癌药物的特点、国内外研究现状、各种脂质体包埋应对肿瘤药物的机制等，综述了脂质体包埋技术在抗癌药物应用中的作用和研究进展，并讨论了其包埋技术在抗肿瘤脂质体药物时的重要性。 关键词：脂质体包埋；抗癌药物；研究进展 Abstract: Liposomes as drug carrier with a new targeting and controlled release of, extended duration of action of drugs, reduce drug toxicity, in the preparation of anti-cancer drugs has been widely used, will be buried in the lipid cancer kits body embedded in the application of liposome technology made of anti-cancer drugs to extend the role of tumor cells selectively concentrated time and located in the monocyte-macrophage cell-rich bone marrow and other tissues in the liver and spleen, so that these parts of the tumor tissue than normal tissue drug concentrations to achieve an effective inhibitory concentration, coated liposome is a new film modified liposomes, compared with ordinary liposomes, increased liposome stability in vivo, extending the in vivo circulation time, increased targeting of drug is liposome-embedded core technology in the forefront of anti-cancer drugs; in recent years, liposomes embedded technology in the treatment of malignant tumors of the performance of anti-cancer drug research a good prospect, according to the liposome-embedded technology, the characteristics of anti-cancer drugs, research status, a variety of liposome-embedded tumor drug response mechanism, an overview of liposome-embedded technology in the anti-cancer drug the role and application of research, and discuss its embedded technology in the anti-tumor drugs liposomes importance。 Key words: liposome-embedded; anti-cancer drugs; Research Bamghman[1]等。他们发现将磷脂分散在水中可以形成封闭、多层的小囊泡。进一步研究发现，这种囊泡是由脂质双分子层组成的，其结构有类似生物膜的特点，以后人们将这种结构的脂质囊泡称为脂质体，1971年，Ryman[2]等人提出：“可以将脂质体用作药物载体，以降低药物的毒、副反应，提高药物的靶向性，同时认为脂质体存在稳定性差、保质期短。”脂质体作为一种抗癌药物给药系统，起