丙二腈类衍生物应用及合成研究进展.pdfVIP

第27卷第9期 化 学 研 究 与 应 用 Vol.27,No.9 　 化 学研 究与应 用 第27 卷　 2015年9月 ChemicalResearchandApplication Sep. ,2015 文章编号:1004-1656(2015)09-1232-07 丙二腈类衍生物应用及合成研究进展 1* 1 2 田宗明 ,秦永华 ,潘再法 (1.浙江医药高等专科学校生物与制药学院,浙江　 宁波　 315100; 2.浙江工业大学化学工程学院,浙江　 杭州　 310000) 摘要:丙二腈类衍生物在农药方面良好的除草、杀菌、杀虫等生物活性得到了深入研究,在医药、染料等方面的 用途也有报道;丙二腈双氰基强吸电子性的特点,导致亚甲基上两个氢都很活泼,容易发生取代、加成、缩合、 消去等反应。 依据丙二腈氰基α位取代基的结构特点将丙二腈衍生物分三类进行归纳:α位为单键的丙二腈 衍生物、α位为双键的丙二腈衍生物、α位为环状结构的丙二腈衍生物,同时介绍了丙二腈类衍生物应用及合 成研究进展。 关键词:丙二腈;衍生物;应用;合成;进展 中图分类号:O622．2　 　 文献标志码:A Recent advance on application and synthesis of malononitrile derivatives 1* 1 2 TIAN Zong-ming ,QIN Yong-hua ,PAN Zai-fa (1．School of Biology and Pharmaceutics,Zhejiang Pharmaceutical College,Ningbo315100,China; 2．College of Chemical Engineering,Zhejiang University of Technology,Hangzhou310000,China) Abstract:Malononitrile derivatives had good herbicidal,fungicidal,insecticide and other biological activity in pesticide．and also had awide range of uses in terms of medicine and dyestuff．Malononitrile dicyano’s strongly electron-withdrawing characteristic made the two methylene hydrogen very active,which was prone to substitution,addition,condensation,elimination and other reac- tions．According to the structural characteristics of malononitrile α-substituent cyano,the malononitrile derivatives could be divided into three categories,namely a single bond α-bit malononitrile derivatives,a double bond α-bit malononitrile derivatives,and a cy- clic structure α-bit malononitr