《Effects of the Interaction betwccn Hydroxyapatite Nanopartieles and Hepatoma Cells.》.pdf
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《Effects of the Interaction betwccn Hydroxyapatite Nanopartieles and Hepatoma Cells.》.pdf
DOI 10.1O07/s11595。014.0970.z
EffectsoftheInteractionbetween
NanopartielesandH epatomaCells
YIN M eizhen1,XUW eiguo~,CU Bing伽InJ,DAIHonglianaA。,H AN n霉chao ,
Ⅵ N Ylxiaa~,LIShipu~
f1.SchoolofMedicine,HubeiPolytechnicUniversity,Huangshi435003,China;2.TongfiHospitalTongfiMedicalCollege,Huazhong
UniversiytofScienceandTechnology,Wuhan43003~Chnia;3.StateKeyLaboratoryofAdvancedTechnoloygforMaterialsSynthesisand
Processing,WuhanUnivers ofTechnology,Wuhan430070,China;4.BiomedicalMaterialsandEngineeringCenter,WuhanUniversiytof
Technoloyg,Wuhan43oo7o.China)
AIMmmet=Togainabetterunderstandingoftheanticancereffectsofhydroxyapatite(HAP)nanoparticles
invivoandinvitro。hteeffectsofhtemteracfion0fHAPnnaoparticleswiht hepaotmacellswereexplored.HAP
nanoparticleswerepreparedbyhomogeneousprecipitationandcharacterizedbylaserparticlenaalysisnad
transmissionelecrtonmicroscopy(TEM).HAPnanoparticleswereobservedtobeuniofrilllydistributed.witll
rod-likeshapesanddiametersintherna geof42.1-87.1nn1.Overnightattached.suspended.nadprolifreating
Bel-7402cellswereincubatedwithHAPnanoparticles.InvertedmicroscopyobservationrevealedhtatHAP
nnaoparticleswithacellmembraneshowedgoodadsorption.TEM demonstratedhtatHAPnanoparticleswere
presentonhtesurfaceofcells,continuouslytakenupbycellsthroughendocytosis,andtransportednivesicles
closetohtenucleus.Fluorescencemi croscopyshowedthathteconcentrationsofintracellularCa2+labeledwim
Fluo一3calcium fluorescentprobeweresignificantlyenhnaced.Inaddition,invertedmicroscopyobservation
revealedthatsuspendedce
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