《Effects of the Interaction betwccn Hydroxyapatite Nanopartieles and Hepatoma Cells.》.pdf

《Effects of the Interaction betwccn Hydroxyapatite Nanopartieles and Hepatoma Cells.》.pdf

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《Effects of the Interaction betwccn Hydroxyapatite Nanopartieles and Hepatoma Cells.》.pdf

DOI 10.1O07/s11595。014.0970.z EffectsoftheInteractionbetween NanopartielesandH epatomaCells YIN M eizhen1,XUW eiguo~,CU Bing伽InJ,DAIHonglianaA。,H AN n霉chao , Ⅵ N Ylxiaa~,LIShipu~ f1.SchoolofMedicine,HubeiPolytechnicUniversity,Huangshi435003,China;2.TongfiHospitalTongfiMedicalCollege,Huazhong UniversiytofScienceandTechnology,Wuhan43003~Chnia;3.StateKeyLaboratoryofAdvancedTechnoloygforMaterialsSynthesisand Processing,WuhanUnivers ofTechnology,Wuhan430070,China;4.BiomedicalMaterialsandEngineeringCenter,WuhanUniversiytof Technoloyg,Wuhan43oo7o.China) AIMmmet=Togainabetterunderstandingoftheanticancereffectsofhydroxyapatite(HAP)nanoparticles invivoandinvitro。hteeffectsofhtemteracfion0fHAPnnaoparticleswiht hepaotmacellswereexplored.HAP nanoparticleswerepreparedbyhomogeneousprecipitationandcharacterizedbylaserparticlenaalysisnad transmissionelecrtonmicroscopy(TEM).HAPnanoparticleswereobservedtobeuniofrilllydistributed.witll rod-likeshapesanddiametersintherna geof42.1-87.1nn1.Overnightattached.suspended.nadprolifreating Bel-7402cellswereincubatedwithHAPnanoparticles.InvertedmicroscopyobservationrevealedhtatHAP nnaoparticleswithacellmembraneshowedgoodadsorption.TEM demonstratedhtatHAPnanoparticleswere presentonhtesurfaceofcells,continuouslytakenupbycellsthroughendocytosis,andtransportednivesicles closetohtenucleus.Fluorescencemi croscopyshowedthathteconcentrationsofintracellularCa2+labeledwim Fluo一3calcium fluorescentprobeweresignificantlyenhnaced.Inaddition,invertedmicroscopyobservation revealedthatsuspendedce

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