药剂班张泽毅《镍钛合金支架概述及其加工》..docVIP

上海医疗器械高等专科学校 毕业论文 镍钛合金支架概述及其加工 姓 名： 张泽毅 系 部： 医疗器械工程 专 业： 药剂设备制造与维护 班 级： 09药剂1班 指导教师： 杨丽英 周飞 完成日期 2012年6月1日 镍钛合金支架概述及其加工 摘 要 血管内支架目前主要是采用生物医用金属材料镍钛合金，经过特殊的加工制造手段精制而成的一种专门用于治疗人体血管管腔狭窄或闭塞的管状器件。迄今为止，临床上应用最广的当属冠状动脉支架与外周血管支架。支架不仅要求其材料具有良好的生物相容性，而且对其加工处理工艺也有着非常严格的要求。 首先,本文介绍了镍钛合金的发展，镍钛合金具有超弹性变形行为，利用这一特性制备的自膨胀支架具有优异的生物相容性和力学性能。其次，介绍了支架加工技术的发展，以及目前激光雕刻支架对于设备与管材的性能要求。利用高功率光纤激光器解决了支架三维雕刻的问题，得出了不锈钢与镍钛合金支架相应的加工工艺参数。对于支架的后处理，主要介绍了酸洗、抛光、钝化对于支架表面粗糙度、耐蚀性以及血液相容性的影响。在本文工艺指导下，处理后的支架在表面质量方面己经达到甚至超过了进口支架的水平。 关键词：Stent overview and its processing ABSTRACT Endocaseular stents are usually made of biocompatible metals by special manufacture poreess and they are used to treat the srticture and oeeulsion of the vascular lumen. Currently，coronary stents and peripheral vascuheral stents are widely used in clinic.There are very strict requirements for not only the biocompatibility of the sent material,but also the manufacture of the stents. Firstly,the development of the manufacture of the NiTi alloy,NiTi alloy provides superelasticity.We can use this porperty to make self-expanded stent,which takes on excellent biocompatiblity and mechanical properties.Secondly,the development of the manufacture of the stent and the requirements for the laser-cutting equipment and 316L stainless steel tubes are introduced in this paper.The parameters for laser cutting of 316L stainless steel stent and Nitinol stent are concluded by using high power optical fiber laser.The influence of acid pickling,polishing and passivation on thesurface quailty,corrosion resistance and blood compatibility of the material is summarized .The surface quality of the stent,which is manufactured under the guide of this work,is even better than that of the importation stents. Key Words: Endovascular， NiTi alloy，stent 、Manufacture 目 录 第1章 绪论……………………………………………………………………………….……1 第2章 形状记忆合金……………………………………………………………….………..2 2.1 形状记忆合金概述…………………………………………………………………..2 2.1.