整合素αvβ3受体显像无创性评估大鼠肝纤维化的可行性的研究.pdf

目 录 英 文 缩 略语 ·······················································································… … 1 中文 摘 要 ··························································································… … 2 英 文 摘 要 ··························································································… … 7 前 言 ································································································… … 14 第 一 部 分 大 鼠 H SC 的分 离 、培 养 、鉴 定 和 诱 导体 外 活 化 前 言 ···········································································… … 16 材 料 与 方 法 ··································································… … 16 结 果 ···········································································… … 20 讨 论 ···········································································… … 22 第 二 部 分 整 合 素 a v邵 在 HSC 活化 过 程 中 的表 达 前 言 ···········································································… … 24 材 料 与 方 法 ··································································… … 24 结 果 ···········································································… … 31 讨 论 ···········································································… … 35 第 三 部 分 整 合 素 a vp 3 RGD 环 肤 配 基 与 Hsc 的结 合 前 言 ···········································································… … 3S 材 料 与 方 法 ··································································… … 3S 结 果 ···········································································… … 43 讨 论 ···········································································… … 47 第 四部 分 肝 纤 维 化 中整 合 素 a v邵 的表 达 和 血 管 新 生 前 言 ·························