β环糊精的改性及催化Suzuki交联偶合反应研究.docVIP

β-环糊精的改性及催化Suzuki交联偶合反应研究 摘 要 β-环糊精（β-cyclodexrin，简称β-CD）是由个葡萄糖单元以α-1,4糖苷键连接起来的环状结构化合物。 本课题的内容对β-CD进行改性，β-CD衍生物的性质。其中，制备得到了马来酸酐-β-CD、羧甲基β-CD和GTA-β-CD，并考察β-CD对于反应的催化效果。-β-CD是由β-CD和氯乙酸钠GTA-β-CD是由GTA和β-CD在NaOH碱性条件下反应制得；马来酸酐-β-CD是由马来酸酐和β-CD在DMF下反应制得。对上述三种环糊精衍生物的结构进行了分析和表征。用制得的β-CD与PdCl2在水相中反应，得到澄清的催化剂体系。考察缚酸剂、催化剂用量、反应温度、对反应的影响。 关键词：β-CD，钯催化，  THE MODIFICATION AND APPLICATION OF β-CYCLODEXTRIN ABSTRACT β-cyclodextrin is a kind of cyclic oligosaccharides consisting of 7 glucose units attached by α-1,4-linkages. This topic research content is mainly to modification of β-CD, study the properties of the part of the β-CD derivatives, including the preparation of the maleic anhydride-β-CD，carboxymethyl-β-CD and GTA -β-CD, and examines the maleic anhydride-β-CD to the catalytic effect of Suzuki reaction. Synthesis of carboxymethyl-β-CD is: β-CD and sodium chloroacetate in KOH alkaline reaction conditions; GTA-β-CDs with GTA and β-CD under the condition of NaOH alkaline reaction system; malefic anhydride-β-CDs with maleic anhydride and β-CD reaction obtained in DMF. The structure of the three kinds of cyclodextrin derivatives are analyzed and characterized. Use of maleic anhydride acylated β-CD and PdCl2 in aqueous phase reaction, clear bright yellow catalyst system can be obtained. The bound acid agent, catalyst dosage, reaction temperature, reaction time, factors and such as substrate universality are examined on the Suzuki cross-coupling reaction. The experimental results show that the synthesis catalyst system in catalyst 0.05mol%, temperature 50℃, bound acid as Na2CO3, reaction time of 5h, the substrate has higher catalytic production rate. KEY WORDS: β-CD, Maleic anhydride, Pd catalyst, Suzuki cross-coupling reaction, conversion rate  目 录 第一章 概述 1 §1.1 环糊精的结构与性质 1 §1.1.1 环糊精简介 1 §1.1.2 环糊精的结构 §1.1.3 环糊精的性质 3 §1.2 环糊精的改性 4 §1.2.1 环糊精改性的目的 §1.2.2 改性环糊精的种类 §1.2.3 环糊精改性的方法 5 §1.3 Suzuki交联偶合反应 §1.3.1 Suzuki反应概述 6 §1.3.2 Suzuki反应的机理研究 7 §1.3.3 水相Suz