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ECE 738 Advanced Video and Image Processing Project report A Survey of Medical Image Registration Aiming Lu Abstract The purpose of this paper is to present a survey of some of the most widely used medical image registration techniques. It also provided a framework of medical image registration, which may include the selecting of transformation, pre-processing images, choosing a registration algorithm to find the transformation, displaying the registration result and validating the algorithm. Applications of image registration include combining images of the same subject from different modalities, aligning temporal sequences of images to compensate for motion of the subject between scans, image guidance during interventions and aligning images from multiple subjects in cohort studies. Current registration algorithms can in many cases automatically register images that are related by a rigid body transformation. There has also been substantial progress in non-rigid registration algorithms that can compensate for tissue deformation, or align images from different subjects. However many registration problems remain unsolved, and this field will continue to be an active field of research in the future. Introduction Image registration, also referred to as image fusion, superimposition, matching or merge, is the process of matching two images so that corresponding coordinate points in the two images correspond to the same physical region of the scene being imaged. It is a classical problem in many applications where it is necessary to match two or more images of the same scene. The images to be registered might be acquired with different sensors (e.g. sensitive to different parts or different tissues in human body) or the same sensor at different times. Image registration has application in many fields; medical image registration is one of the most successful fields that image registration is used. Medical images are widely used in healthcare and biomedical research.