SDLaunch.pptVIP

OVERVIEW OF THE SYNTHETIC DERIVATIVE June 29, 2012 Melissa Basford, MBA Program Manager – Synthetic Derivative Synthetic Derivative resource overview Rich, multi-source database of de-identified clinical and demographic data Contains ~1.8 million records ~1 million with detailed longitudinal data averaging 100k bytes in size an average of 27 codes per record Records updated over time and are current through August 2011. SD Establishment DE-IDENTIFICATION One way hash Data Parsing Data Parsing Information collected during clinical care Restructuring for research Data export SD Database Access through secured online application Data Types (so far) Narratives, such as: Clinical Notes Discharge Summaries History Physicals Problem Lists Surgical Reports Progress Notes Letters Clinical Communications Diagnostic codes, procedural codes Forms (intake, assessment) Reports (pathology, ECGs, echocardiograms) Lab values and vital signs Medication orders TraceMaster (ECGs), Tumor Registry, STS Registry ?120 SNPs for 7000+ GWAS for 10,500+ samples Technology + policy De-identification Derivation of 128-character identifier (RUI) from the MRN generated by Secure Hash Algorithm (SHA-512) RUI is unique to input, cannot be used to regenerate MRN RUI links data through time and across data sources HIPAA identifiers removed using combination of custom techniques and established de-identification software Restricted access continuous oversight Access restricted to VU; not a public resource IRB approval for study (non-human) Data Use Agreement Audit logs of all searches and data exports Date shift feature Our algorithm shifts the dates within a record by a time period that is consistent within each record, but differs across records up to 364 days backwards e.g. if the date in a particular record is April 1, 2005 and the randomly generated shift is 45 days in the past, then the date in the SD is February 15, 2005) What the SD can’t do Outbreaks and other date-specific studies