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Supplemental Appendix 1. Clinical Research File Preoperative versus postoperative initiation of thromboprophylaxis. Effect on coagulation, fibrinolysis, and bleeding in patients undergoing cemented THA. Patient ID: Number of randomization: Signature: Aims of the study: To see if there are any clinically significant differences in (1) blood loss and (2) bleeding events and blood transfusions comparing preoperative with postoperative initiation of thromboprophylaxis. Hospitalization Day 1: 1. Date (dd/mm/year): ______ 2. Gender (F/M): Female/ male 3. Height (cm): ______ cm 4. Weight (kg): ______ kg 5. Body mass index (BMI = weight/height x height): ______kg/m 2 Inclusion: Yes No Primary coxarthrosis ? ? 50 years or older ? ? Cemented Exeter THA ? ? Signed written consent and patient information ? ? Exclusion: Yes No Bleeding disorder or bleeding tendency Coagulation disorder ? ? History of venous thromboembolism, deep venous thrombosis, or pulmonary embolism ? ? NSAIDS with a half-life of 18 hours or more during last week ? ? Active malignancy ? ? Myocardial infarction last 3 months Stroke last 3 months ? ? Major trauma last 3 months Chronic lung disease ? ? Allergy to low molecular-weight heparin Alcohol or drug abuse ? ? Liver disease Renal failure Concomitant disease: Medication: Laboratory tests Day 1: Hemoglobin (g/dL): _____ Hematocrit (%): _____ Thrombocytes: _____ C reactive protein (mg/dL): _____ Creatinine: _____ Aspartate amino transferase (ASAT) Alanine amino transferase (ALAT): _____ Preoperative injection: Date (dd/mm/year): _________ Time (hours:minutes): ______ Day of surgery -