AntibioticBasicsPart2Final2011.ppt.ppt

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Arabinogalactan Arabinogalactan is a biopolymer consisting of arabinose and galactose monosaccharides D-Galactose Arabinogalactan-mycolic acid adduct Targets of First Line anti-TB Drugs Overview of anti-mycobacterial drugs Antimicrobial Resistance LINK Assigned Reading: Antibiotic Basics for Clinicians, by Alan R. Hauser, pp. 33—99 Kirkpatrick Peter; Raja Aarti; LaBonte Jason; Lebbos John Daptomycin. Nature reviews. Drug discovery (2003), 2(12), 943-4. Ammerlaan, H. S. M.; Bonten, M. J. M. Daptomycin: graduation day. Clinical Microbiology and Infection (2006), 12(Suppl. 8), 22-28. Baltz, Richard H.; Miao, Vivian; Wrigley, Stephen K. Natural products to drugs: Daptomycin and related lipopeptide antibiotics. Natural Product Reports (2005), 22(6), 717-741. pp. 717-722, 725-726. Baltz Richard H Daptomycin: mechanisms of action and resistance, and biosynthetic engineering. Current opinion in chemical biology (2009), 13(2), 144-51. Journal code: 9811312. Clay Kimberly D; Hanson John S; Pope Scott D; Rissmiller Richard W; Purdum Preston P 3rd; Banks Peter M Brief communication: severe hepatotoxicity of telithromycin: three case reports and literature review. Annals of internal medicine (2006), 144(6), 415-20. Zeitlinger, Markus; Wagner, Claudia Christina; Heinisch, Birgit. Ketolides - the modern relatives of macrolides : the pharmacokinetic perspective. Clinical Pharmacokinetics (2009), 48(1), 23-38. Vicens, Quentin; Westhof, Eric. RNA as a drug target: The case of aminoglycosides. ChemBioChem (2003), 4(10), 1018-1023. Wilson, Daniel N.; Nierhaus, Knud H. The oxazolidinone class of drugs find their orientation on the ribosome. Molecular Cell (2007), 26(4), 460-462. Marchese, A.; Schito, G. C. The oxazolidinones as a new family of antimicrobial agent. Clinical Microbiology and Infection (2001), 7(Suppl. 4), 66-74. Asaka