SerumLevelofRetinolBindingProtein4InPatientswithGestationalDiabetesMellitus.docVIP

妊娠糖尿病视黄醇结合蛋白4血清水平的研究 吴丹冬，任伟1，刘静婧，李素芳，李金超，张素华，郑晓雅 重庆医科大学附属第一医院 400016 [摘要] 目的：探讨妊娠糖尿病个体与非妊娠糖尿病个体血清视黄醇结合蛋白4（RBP4）水平的差异，及其影响因素。方法：收集36例妊娠糖尿病个体，应用ELISA测定血清RBP4水平，同时测定血糖、血脂、胰岛素代谢水平，计算胰岛素抵抗指数（HOMA-IR），并与45例非妊娠糖尿病个体比较。结果：妊娠糖尿病个体血清RBP4水平明显低于非妊娠糖尿病对照组，年龄、HOMA-IR、胰岛素分泌功能（B）高于对照组。多元线性回归分析显示HOMA-IR对RBP4水平没有影响， HDL-c、TC、B是影响妊娠糖尿病个体血清RBP4水平的主要因素。结论：妊娠糖尿病个体血清RBP4水平低于非妊娠糖尿病对照组，这提示单纯血清RBP-4水平可能不是评估妊娠时胰岛素-葡萄糖稳态的有效指标。 [关键词] 妊娠糖尿病；胰岛素抵抗；RBP-4 [中图分类号] R587.1 [文献标识码] A Serum Level of Retinol Binding Protein 4 In Patients with Gestational Diabetes Mellitus WU Dandong, REN Wei，Liu Jingjing，Li Sufang，Li Jinchao，Zhang Suhua，Zheng Xiaoya (Department of Endocrinology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016,China) [Abstract] Objective: To study the deference of the serum level of retinol binding protein 4 between gestational diabetes mellitus and non-gestational diabetes mellitus, and the influence factors of the serum level of retinol binding protein 4. Methods: To measure serum RBP4 by ELISA, blood glucose, blood lipid, serum insulin and calculate HOMA-IR in 36 gestational diabetes mellitus(GDM), and compare with 45 non-gestational diabetes mellitus. Restults: Women with gestational diabetes had lower level of RBP4 than controls，but higher age, HOMA-IR and B. The multiple linear regressions analysis showed that the level of RBP4 was not affected by HOMA-IR, but HDL-c、TC、B in GDM group. Conclusion: Women with gestational diabetes have lower level of RBP4. RBP4 does not seem to be a valuable marker for identification of the insulin-glucose homeostasis during pregnancy. [Keywords]: Gestational diabetes mellitus；insulin resistance；Retinol binding protein4. 过去一直认为视黄醇结合蛋白4（RBP4）与相关的多项指标关系密切,可能是一项新型血清标志物））C冰箱冻存。葡萄糖测定用葡萄糖氧化酶法，采用中生北控生物科技股份有限公司试剂盒。血脂测定用酶学方法。血浆胰岛素用化学发光法，采用德国罗氏诊断有限公司试剂盒。血清RBP4用ELISA法，采用RD公司试剂盒。体重指数（BMI））））uU/ml) 9.06?.05 8.00?.82 0.165 BPTG( mmol/L) 3