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DNA methylation program during development.pdf
Front．Bio1．2012，7(6)：485-494
D0Il0．1007／sl15l5—012．9246．1
DNAmethylationprogram duringdevelopment
FengC．ZHOU(圜)
DepartmentofAnatomyandCellBiology,StarkNeuroscienceResearchInstitute,IndianaUniversitySchoolMedicine,Indianapolis,IN
46202,USA
◎HigherEducationPressandSpringer-VerlagBerlinHeidelberg2012
Abstract DNA methylationisakeyepigeneticmarkwhenoccurringinthepromoterandenhancerregionsregulates
theaccessibilityofthebindingproteinandgenetranscription．DNA methylation isinheritableandcanbe novo-
synthesized，erasedandreinstated，makingitarguablyoneofthemostdynamicupstream regulatorsforgen
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