原创力文档Enzymatic Synthesis of Halogen Derivatives of Aromatic Amino Acids Labeled with Hydrogen Isotopes.pdfVIP
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Enzymatic Synthesis of Halogen Derivatives of Aromatic Amino Acids Labeled with Hydrogen Isotopes.pdf
J．Chem．Chem．Eng．8(2014)54-60
EnzymaticSynthesisofHalogenDerivativesofAromatic
Am inoAcidsLabeledwithHydrogenIsotopes
ElzbietaWinnicka，MatgorzataPaj冰，KatarzynaPa／ka，KatarzynaCzerwifiskaandMariannaKafiska
DepartmentofChemistry，UniversityofWarsaw，Warsaw02—093，Poland
Received：Octoberl7，2013／Accepted：November30,2013／Published：January25，2014
Abstract：Theisotopomersofhalogenatedaminoacids(2-F-L-phenylalanine，3-F-and3-CI-L-tyrosine，aswellas5-F一，5-Br-
and6-F—L-tryptophan1specificallylabeledwithdeuteriumat0一【and3[-carbonatomofthesidechainweresynthesizedbyenzymatic
catalyzedH ／D exchangeinfullyd
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