HE4全新卵巢癌标志物.ppt

卵巢癌血清学标志物的检测 血清学肿瘤标志物检测的优势： 比影像学检测更敏感，更提前 血清检测更简便、检测结果结果客观 在肿瘤筛查、诊断、疗效判断、复发检测等方面应用广泛 ARCHITECT ROMA准确性：评价卵巢癌风险的灵敏度达86.9%，阴性预测值达94.5% Disease Low Risk (N) High Risk (N) All (N) Sensitivity (%) Specificity (%) PPV (%) NPV (%) Benign 393 89 482 86.9 81.5 66 94.5 EOC + LMP 23 152 175 Total 416 241 657 ARCHITECT ROMA准确识别卵巢癌高危患者 不同分期卵巢上皮癌（EOC）分析 Age EOC Stage Total EOC % EOC Misclassified I II III IV Not Staged Premenopausal 12 classified as low risk 6 1 2 3 74 16.2% (12/74) Postmenopausal 6 classified as low risk 1 1 0 4 81 7.4% (6/81)