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Available online at Journal of Controlled Release 127 (2008) 41 – 49 /locate/jconrel Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice Jong-Ho Kim a,1 , Yoo-Shin Kim b,1 , Kyeongsoon Park a , Seulki Lee a , Hae Yun Nam a,c , Kyung Hyun Min a,d , Hyung Gon Jo a,d , Jae Hyung Park c , Kuiwon Choi a , Seo Young Jeong d , Rang-Woon Park b , In-San Kim b , Kwangmeyung Kim a,⁎, Ick Chan Kwon a a Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, South Korea b Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, 101 Dongin-dong, Jung-gu, Daegu 700-422, South Korea c Departments of Advanced Polymer and Nanopharmaceutical Sciences, Kyung Hee University, Gyeonggi-do 449-701, South Korea d Department of Life and Nanopharmaceutical Science, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, South Korea Received 28 September 2007; accepted 13 December 2007 Available online 26 December 2007 Abstract To make a tumor targeting nano-sized drug delivery system, biocompatible and biodegradable glycol chitosan (Mw =250 kDa) was modified with hydrophobic cholanic acid. The resulting hydrophobically modified glycol chitosans (HGCs) that formed nano-sized self-aggregates in an aqueous medium were investigated as an anticancer drug carrier in cancer treatment. In