多肽链修饰.pptVIP

Platelet shape change and aggregation measured by light transmittance using aggregometer (un-stimulated) Platelet shape change response Light transmitted Light transmitted Agonist Agonist Agonist Light transmitted Agonist Platelet aggregation vehicle Functional responses of platelet activation 1) Shape change 2) Aggregation (as a result of αIIbβ3) 3) Secretion of granules 4) Thromboxane A2 (TXA2) production inhibit vWF mediated platelet adhesion inverse agonist inhibit vWF mediated platelet adhesion Marketed Antiplatelet Drugs and the limitations Marketed and clin