Lewis酸诱导芳基三氮烯为底物Stille偶联反应研究有机化学.pdfVIP

DOI: 10.6023/cjoc1201311 研究论文 有机化学 Chinese Journal of Organic Chemistry ARTICLE Lewis 酸诱导芳基三氮烯为底物的Stille 偶联反应研究 南光明*,a 周 均b a ( 伊犁师范学院化学与生物科学学院 新疆凝聚态相变与微结构实验室 伊宁 835000) (b 伊犁出入境检验检疫局综合技术服务中心 伊宁 835000) 摘要 首次以芳基三氮烯为新型亲电底物进行 Stille 偶联反应研究. 反应在室温、氩气保护下进行. 溶剂、两底物物质 的量比、催化剂用量等影响收率的因素被优化, 取得最佳的优化条件, 获得较好的收率. 芳基三氮烯通过助催化剂路易 1 13 斯酸迁移到钯化合物, 偶联反应由钯催化剂催化完成. 产物纯化通过硅胶柱层析完成, 结构被 H NMR, C NMR 确定. 关键词 芳基三氮烯; 偶联反应; 三丁基苯基锡 Study on Lewis Acid Induced the Stille Cross-Coupling Reactions of Aryltriazenes as Substrates Nan, Guangming *,a Zhou, Junb a ( Xinjiang Laboratory of Phas e Transitions and Microstructures of Condensed Matters, College of Chemistry and Biology, Yili Normal University, Yining 835000) b ( Comprehensive Technical Service Centre of Yili Entry-exit Inspection and Quarantine Bureau, Yining 835000) Abstract The Stille cross-coupling reaction of aryltriazene as a novel electrophilic substrate has been realized for the first time. The reactions were performed at room temperature under an argon atmosphere. Solvents, molar ratio of aryltriazene/ tributyl(phenyl)stannane, amount of catalyst were optimized and excellent yield was obtained. Aryltriazene via Lewis acid-assisted was