Aza-BODIPY荧光染料的合成、表征及性能研究有机化学.pdfVIP

2011 年第 31 卷 有 机 化 学 Vol. 31, 2011 第 9 期, 1440～1444 Chinese Journal of Organic Chemistry No. 9, 1440～1444 ·研究论文· Aza-BODIPY 荧光染料的合成、表征及性能研究 * 李翠红 沈田华 陈小利 周彩琪 张 诚 宋庆宝 (浙江工业大学化学工程与材料学院 杭州 310032) 摘要 aza-BODIPY 荧光染料是近 10 年发展起来并受到广泛关注的一类新型荧光化合物, 它极有可能发展成可应用于 光动力学治疗的光敏剂. 本工作合成了 5 个 aza-BODIPY 1a～1e, 用 IR, NMR, MS 和元素分析对它们进行了表征. 研究 了它们的紫外吸收光谱与荧光发射光谱, 结果表明 1a～1e 具有较高的摩尔吸光系数, 在 aza-BODIPY 母环的 3,5 位或 1,7 位的苯环 4 位有供电子取代基时能使化合物的最大紫外吸收波长和荧光发射波长红移. 测试了 1a～1d 的循环伏安 曲线, 根据各化合物的氧化还原电位讨论了它们的结构稳定性. 关键词 aza-BODIPY; 荧光染料; 紫外吸收光谱; 荧光发射光谱; 循环伏安 Synthesis, Characterization and Properties of Aza-BODIPY Fluorescent Dyes Li, Cuihong Shen, Tianhua Chen, Xiaoli Zhou, Caiqi Zhang, Cheng Song, Qingbao* (College of Chemical Engineering Materials Science, Zhejiang University of Technology, Hangzhou 310032) Abstract A relatively new kind of aza-BODIPY fluorescent compound has been developed and aroused wide attention in the last decade. They are potentially useful photosensitizer for photodynamic therapy. In this work, five aza-BODIPY fluorescent dyes 1a～1e have been synthesized. All the compounds have been identified by IR, NMR, MS techniques and elemental analysis. Their spectra of UV absorption and fluores- cence emission have been also measured. A conclusion can be drawn that aza-BODIPY fluorescent dyes 1a～1e have high molar extinctio