A Bayesian Approach for Decision Making on the Identification of Genes with Different Expression Levels An Application to Escherichia coli Bacterium Data.pdfVIP

Hindawi Publishing Corporation Computational and Mathematical Methods in Medicine Volume 2012, Article ID 953086, 13 pages doi:10.1155/2012/953086 Research Article A Bayesian Approach for Decision Making on the Identification of Genes with Different Expression Levels: An Application to Escherichia coli Bacterium Data 1 2 ´ 3 3 2 Erlandson F. Saraiva, Francisco Louzada, Luıs A. Milan, Silvana Meira, and Juliana Cobre 1 FACET, Universidade Federal da Grande Dourados, Brazil 2 ICMC, Universidade de Sao Paulo, Brazil ˜ 3 DEs, Universidade Federal de Sao, Carlos, Brazil ˜ Correspondence should be addressed to Francisco Louzada, louzada@icmc.usp.br Received 20 September 2011; Revised 20 November 2011; Accepted 24 November 2011 Academic Editor: Niko Beerenwinkel Copyright © 2012 Erlandson F. Saraiva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A common interest in gene expression data analysis is to identify from a large pool of candidate genes the genes that present significant changes in expression levels between a treatment and a control biological condition. Usually, it is done using a statistic value and a cutoff value that are used to separate the genes differentially and nondifferentially expressed. In this paper, we propose a Bayesian approach to identify genes differentially expressed calculating sequentially credibility intervals from predictive densities