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A Mathematical Model of HIV Transmission in Homosexuals with Genetic Heterogeneity.pdf
Journal of Theoretical Medrcinc, Vol. 2, pp. 285-296 @ 2000 OPA (Overseas Puhl~shersAssoc~atmn)N.V.
Reprlnts ava~labledirectly from the publisher Published hy license under
Photocopying permitted by license only the Gordon and Breach Scienct
Publ~shersimpr~nt
Prlnted in Malaysia.
A Mathematical Model of HIV Transmission in
Homosexuals With Genetic Heterogeneity
SHU-FANG HSU SCHMITT
Institut fur Mathematische Statistik und Ver~icherungslehre(IMSV), Universitat Bern, 3012 Bern, Swit,-erland
(Received 22 November 1998: In final form 9 August 1999)
Several AIDS cohort studies observe that the incubation period between HIV infection
and AIDS onset can be shorter than 3 years in about 10% seropositive individuals, or
longer than 10 years in about 10-15% individuals. On the other hand, many individuals
remain seronegative even after multiple exposures to HIV. These distinct outcomes have
recently been correlated with some mutant genes in HIV co-receptors (e.g., CCR5,CCR2
and CXCR4). For instance, the muta
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