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A Mathematical Tumor Model with Immune Resistance and Drug Therapy An Optimal Control Approach.pdf
.lournu/ of Tlreorrrrcnl Medicine. Vol. 3, pp. 79-100 02001 OPA (O\erreas Puhli4irr\ Awmatron) N.V.
Reprinti ava~labledmctly from the poblkhcr Iubllihed by hcense under
Phutocopyinp pemimed by license only the Gordon and Breach Sclence
Pubhshers imonlit
A Mathematical n m o r Model with Immune Resistance
and Drug Therapy: an Optimal Control Approach
L.G. DE PILLIS.* and A. RADUNSKAYA~~~
College, Claremont,
~ a r v eMuddy College, Clnrernunt, CA 91 711,and Argonne National Lnboratoq Argorme, IL 60439 and b ~ o m o r ~ a
CA 91 711
(ReceivedDecernbes 1999;In final form April 18, 2000)
We present a competition model of cancer tumor growth that includes both the immune sys-
tem response and drug therapy. This is a four-population model that includes tumor cells, host
cells, immune cells, and drug interaction. We analyze the stability of the drug-free equilibria
with respect to the immune response in order to look for target basins of attraction. One of our
goals was to simulate qualitatively the asynchronous tumor-drug interaction known as Jeff s
phenomenon. The model we develop is successful in generating this asynchronous response
behavior. Our other goal was to id
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