A Review on Current Osteoporosis Research With Special Focus on Disuse Bone Loss.pdfVIP

SAGE-Hindawi Access to Research Journal of Osteoporosis Volume 2011, Article ID 293808, 6 pages doi:10.4061/2011/293808 Review Article A Review on Current Osteoporosis Research: With Special Focus on Disuse Bone Loss Roy Yuen-chi Lau and Xia Guo Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Correspondence should be addressed to Xia Guo, rsguoxia@.hk Received 14 March 2011; Revised 26 June 2011; Accepted 29 June 2011 Academic Editor: Merry Jo Oursler Copyright © 2011 R. Y.-c. Lau and X. Guo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Osteoporosis is a multifactorial skeletal disorder characterized by decreased bone mass and deteriorated microarchitecture that lead to increased risk of fracture. The disuse osteoporosis refers to bone mass decrements under conditions of decreased mechanical loading, including decreased ground force reaction, muscular contraction, and microgravity-related bone loss in astronauts after space flights. Although there are many effective treatments available for primary osteoporosis, there is a lack of effective treatments for disuse osteoporosis. This is because that the aetiology, pathophysiology, and resultant pathology of disuse osteoporosis differ from those of primary osteoporosis. The objective of this paper is to examine the unique pathology and underlying pathophysiology of disuse osteoporosis. 1. Introduction of trochanter and femoral neck in women with weight