A Study of the Temperature Dependence of Bienzyme Systems and Enzymatic Chains.pdfVIP

Computational and Mathematical Methods in Medicine, Vol. 8, No. 2, June 2007, 93–112 A study of the temperature dependence of bienzyme systems and enzymatic chains N. V. KOTOV†, R. E. BAKER‡*, D. A. DAWIDOV†, K. V. PLATOV†, N. V. VALEYEV{#, A. I. SKORINKIN†§ and P. K. MAINI‡ k †Laboratory of Biophysics and Bionics, Physics Department, Kazan State University, Kazan 420018, Russia ‡Centre for Mathematical Biology, Mathematical Institute, University of Oxford, 24-29 St. Giles, Oxford OX1 3LB, UK {Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK §Kazan Institute of Biochemistry and Biophysics, Kazan State University, Russian Academy of Sciences, Kazan 420018, Russia kDepartment of Biochemistry, Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford OX1 3QU, UK #Systems Biology Lab, Department of Engineering, University of Leicester, University Road, Leicester LE1 7RH, UK (Received 6 October 2006; revised 16 March 2007; in final form 28 March 2007) It is known that most enzyme-facilitated reactions are highly temperature dependent processes. In general, the temperature coefficient, Q10, of a simple reaction reaches 2.0–3.0. Nevertheless, some enzyme-controlled processes have much lower Q10 (about 1.0), which implies that the process is almost temperature independent, even if individual reactions involved in the process are themselves highly temperature dependent. In this work, we investigate a possible mechanism for this apparent temperature compensation: simple mathematical models a