Crosstalk between Iron Metabolism and Erythropoiesis.pdfVIP

Hindawi Publishing Corporation Advances in Hematology Volume 2010, Article ID 605435, 12 pages doi:10.1155/2010/605435 Review Article Crosstalk between Iron Metabolism and Erythropoiesis Huihui Li and Yelena Z. Ginzburg Lindsley F. Kimball Research Institute, New York Blood Center, 310 East 67th Street, 1–38, NY 10065, USA Correspondence should be addressed to Yelena Z. Ginzburg, yginzburg@ Received 21 January 2010; Accepted 25 March 2010 Academic Editor: Stefano Rivella Copyright © 2010 H. Li and Y. Z. Ginzburg. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Iron metabolism and erythropoiesis are inextricably linked. The majority of iron extracted from circulation daily is used for hemoglobin synthesis. In the last 15 years, major advances have been made in understanding the pathways regulating iron metabolism. Hepcidin is a key regulator of iron absorption and recycling and is itself regulated by erythropoiesis. While several viable candidates have been proposed, elucidating the “erythroid regulator” of hepcidin continues to generate significant experimental activity in the field. Although the mechanism responsible for sensing iron demand for erythropoiesis is still incompletely understood, evaluating diseases in which disordered erythropoiesis and/or iron metabolism are showcased has resulted in a more robust appreciation of potential candidates coordinated erythroid iron demand with regulators of iron supply. We present data drawn from four different conditions—iron deficiency, congenital hypotransferrinemia, beta-thalassemia,