Development of Screening Tools for the Interpretation of Chemical Biomonitoring Data.pdfVIP

Hindawi Publishing Corporation Journal of Toxicology Volume 2012, Article ID 941082, 10 pages doi:10.1155/2012/941082 Review Article Development of Screening Tools for the Interpretation of Chemical Biomonitoring Data Richard A. Becker,1 Sean M. Hays,2 Steven Robison,3 and Lesa L. Aylward4 1 Regulatory and Technical Aff airs Department, American Chemistry Council, Washington, DC 20002, USA 2 Summit Toxicology, LLP, Lyons, CO 80540, USA 3 Central Product Safety, Procter Gamble, Cincinnati, OH 45253, USA 4 Summit Toxicology, LLP, Falls Church, VA 22044, USA Correspondence should be addressed to Lesa L. Aylward, laylward@ Received 26 August 2011; Accepted 5 December 2011 Academic Editor: Jane C. Caldwell Copyright © 2012 Richard A. Becker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Evaluation of a larger number of chemicals in commerce from the perspective of potential human health risk has become a focus of attention in North America and Europe. Screening-level chemical risk assessment evaluations consider both exposure and hazard. Exposures are increasingly being evaluated through biomonitoring studies in humans. Interpreting human biomonitoring results requires comparison to toxicity guidance values. However, conventional chemical-specific risk assessments result in identification of toxicity-based exposure guidance values such as tolerable daily intakes (TDIs) as applied doses that cannot directly be used to evaluate exposure information provided by biomonitoring data in a health risk context. This paper describes a variety of approaches for development