Effects of Supraphysiological Doses of Levothyroxine on Sleep in Healthy Subjects A Prospective Polysomnography Study.pdfVIP

SAGE-Hindawi Access to Research Journal of Thyroid Research Volume 2011, Article ID 420580, 7 pages doi:10.4061/2011/420580 Research Article Effects of Supraphysiological Doses of Levothyroxine on Sleep in Healthy Subjects: A Prospective Polysomnography Study Susanne Kraemer,1 Heidi Danker-Hopfe,2 Maximilian Pilhatsch,3 Frederik Bes,4 and Michael Bauer3 1 Bodelschwinghstraße 85, 33604 Bielefeld, Germany 2 Department of Psychiatry and Psychotherapy, Charite—University Medicine 14050 Berlin, Campus Benjamin Franklin, Berlin, ´ Germany 3 Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universitat Dresden, ¨ Fetscherstraße 74, 01307 Dresden, Germany 4 Embla Systems BV, 1043 Amsterdam, The Netherlands Correspondence should be addressed to Michael Bauer, michael.bauer@uniklinikum-dresden.de Received 22 November 2010; Accepted 13 May 2011 Academic Editor: B. Stack Copyright © 2011 Susanne Kraemer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Disrupted sleep is prevalent in both mood and thyroid disorders. Given the emerging use of thyroid hormones in the treatment of mood disorders, we investigated the effects of supraphysiological doses of levothyroxine (L-T4) on sleep. In an open-label design, 13 healthy subjects received up to 500 µg/day for an eight-week period. A baseline night was polysomnographically