First- and Second-Trimester Reference Intervals for Thyroid Hormones during Pregnancy in “Rhea” Mother-Child Cohort, Crete, Greece.pdfVIP

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First- and Second-Trimester Reference Intervals for Thyroid Hormones during Pregnancy in “Rhea” Mother-Child Cohort, Crete, Greece.pdf

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First- and Second-Trimester Reference Intervals for Thyroid Hormones during Pregnancy in “Rhea” Mother-Child Cohort, Crete, Greece.pdf

SAGE-Hindawi Access to Research Journal of Thyroid Research Volume 2011, Article ID 490783, 12 pages doi:10.4061/2011/490783 Research Article First- and Second-Trimester Reference Intervals for Thyroid Hormones during Pregnancy in “Rhea” Mother-Child Cohort, Crete, Greece Polyxeni Karakosta,1, 2 Leda Chatzi,1 Emmanouil Bagkeris,1 Vasiliki Daraki,3 Dimitris Alegakis,1 Elias Castanas,2 Manolis Kogevinas,4, 5 and Marilena Kampa2 1 Department of Social Medicine, Faculty of Medicine, University of Crete, P.O. Box 2208, 71003 Heraklion, Greece 2 Department of Experimental Endocrinology, Faculty of Medicine, University of Crete, P.O. Box 2208, 71003 Heraklion, Greece 3 Department of Endocrinology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece 4 Centre for Research in Environmental Epidemiology (CREAL), Doctor Aiguader, 88, 08003 Barcelona, Spain 5 National School of Public Health, Alexandras Avenue 196, 115 21 Athens, Greece Correspondence should be addressed to Polyxeni Karakosta, p karakosta@ Received 4 May 2011; Revised 26 August 2011; Accepted 9 September 2011 Academic Editor: Duncan Topliss Copyright © 2011 Polyxeni Karakosta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Estimation and interpretation of thyroid function tests in pregnant women is of utmost importance for maternal, fetal and neonatal health. Our objective was to calculate laboratory- and geography-speciﬁc reference intervals for thyroid hormones during pregnancy in an iodine-suﬃcient area of the Mediterranean, Crete, Greece. This project was performed in the context of “Rhea” mother-c